منابع مشابه
Pharmacology of the HMG-CoA reductase inhibitors
Pleiotropic effects are now described for the 3-hydroxy-3methylglutaryl-coenzyme A reductase inhibitors (or statins) that might have utility in the context of chronic inflammatory autoimmune disease. Here we discuss the pharmacology and established uses of statins and in this context describe potential anti-inflammatory and immune-modulatory effects. An extensive in vitro data set defines roles...
متن کاملHMG-CoA reductase inhibitors and renal function.
Experimental Evidence for a Role of Dyslipidemia in Renal Injury and for a Renal Protective Effect of Statins T he presence of lipids in renal cells upregulates intracellular signaling pathways involved in inflammatory and fibrogenic responses, both of which are components of progressive renal injury. Lipids activate various growth factors that cause mesangial cell proliferation. Mesangial cell...
متن کاملRenal tubular toxicity of HMG-CoA reductase inhibitors.
A patient developed direct renal tubular toxicity on high-dose HMG-CoA reductase inhibitor (statin) therapy. Considerable renal damage was present by the time the injury became apparent. Urine abnormalities regressed after stopping the drug and reappeared after about 2 weeks following re-challenge. Although tubular damage may be slight and relatively difficult to detect, it is possible that cum...
متن کاملPleiotropic effects of the HMG-CoA reductase inhibitors
The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes. These secondary actions are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropy of statins and emphasizes the importance of randomized placebo-controlled trials to furth...
متن کاملHMG-CoA Reductase Inhibitors Improve Acute Ischemic Stroke Outcome
Background and Purpose—Statins reduce the risk of stroke recurrence, but the benefits of statins in improving outcome of acute stroke patients have not been well explored. Methods—We assessed potential effects of statins initiated before or within 4 weeks of stroke on 90-day outcome. Favorable outcomes were National Institutes of Health Stroke Scale (NIHSS) score 2 at 12 weeks and modified Rank...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1990
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.18.2_165